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Fifty percent inhibitory concentrations for the inhibition of NA by oseltamivir carboxylatea
| Virus | IC50 (nM)b | |
|---|---|---|
| Native viral NA (A/WS/33, H1N1) | ||
| Wild type | 1.0 | |
| His274Tyr | 300 | |
| Recombinant NA (A/WS/33, H1N1) | ||
| Wild type | 1.1 | |
| His274Tyr | 200 | |
| Recombinant NA (A/Tokyo/3/67, H3N2) | ||
| Wild type | 0.4 | |
| His274Tyr | 1.0 |
Values were means of data from three or more independent experiments. Standard deviations were less than 8% of the mean value.
IC50, 50% inhibitory concentration.
