TABLE II. Performance on Nuclei Segmentation Using Different Methods to Handle Stain Variation. The Best Performance is Denoted in Bold. The Bootstrapped 95 Confidence Intervals are Shown in Brackets. The Overall Performance is the Mean Performance Across the Four Datasets.

	CoNSeP		CRAG		GlaS		PanNuke		Overall
Method	()	()	()	()	()	()	()	()	()	()
Baseline	0.671 (0.010)	0.505 (0.008)	0.614 (0.003)	0.471 (0.002)	0.691 (0.003)	0.531 (0.003)	0.711 (0.009)	0.539 (0.007)	0.672 (0.006)	0.512 (0.005)
HM [10]	0.645 (0.012)	0.479 (0.010)	0.567 (0.003)	0.430 (0.003)	0.668 (0.004)	0.507 (0.003)	0.676 (0.011)	0.511 (0.009)	0.639 (0.008)	0.482 (0.006)
FDA [11]	0.597 (0.015)	0.438 (0.011)	0.506 (0.004)	0.382 (0.003)	0.657 (0.004)	0.496 (0.003)	0.624 (0.013)	0.465 (0.01)	0.596 (0.009)	0.445 (0.007)
Reinhard et al. [14]	0.646 (0.011)	0.482 (0.009)	0.603 (0.003)	0.460 (0.002)	0.666 (0.004)	0.510 (0.003)	0.692 (0.009)	0.522 (0.007)	0.652 (0.007)	0.494 (0.005)
Macenko et al. [16]	0.631 (0.013)	0.472 (0.010)	0.518 (0.004)	0.391 (0.003)	0.665 (0.003)	0.503 (0.003)	0.674 (0.011)	0.507 (0.009)	0.622 (0.008)	0.468 (0.006)
SPCN [18]	0.613 (0.013)	0.458 (0.010)	0.522 (0.004)	0.394 (0.003)	0.667 (0.004)	0.504 (0.003)	0.640 (0.013)	0.477 (0.010)	0.611 (0.009)	0.458 (0.007)
ACD [19]	0.644 (0.013)	0.484 (0.010)	0.527 (0.004)	0.403 (0.003)	0.702 (0.003)	0.538 (0.003)	0.691 (0.011)	0.523 (0.009)	0.641 (0.008)	0.487 (0.006)
StainGAN [22]	0.500 (0.016)	0.362 (0.012)	0.552 (0.003)	0.414 (0.002)	0.540 (0.004)	0.388 (0.003)	0.568 (0.013)	0.420 (0.010)	0.540 (0.009)	0.396 (0.007)
Stain Jitter [27]	0.692 (0.009)	0.521 (0.008)	0.677 (0.002)	0.518 (0.002)	0.704 (0.003)	0.530 (0.003)	0.720 (0.007)	0.547 (0.006)	0.698 (0.005)	0.529 (0.005)
RandStainNA [29]	0.682 (0.009)	0.513 (0.008)	0.613 (0.003)	0.469 (0.002)	0.677 (0.003)	0.520 (0.003)	0.715 (0.008)	0.543 (0.007)	0.672 (0.006)	0.511 (0.005)
H&E Adversarial [34]	0.680 (0.010)	0.509 (0.008)	0.639 (0.003)	0.489 (0.002)	0.683 (0.003)	0.524 (0.003)	0.719 (0.009)	0.546 (0.007)	0.680 (0.006)	0.517 (0.005)
SCA (proposed)	0.695 (0.010)	0.524 (0.008)	0.685 (0.002)	0.526 (0.002)	0.719 (0.003)	0.545 (0.003)	0.723 (0.008)	0.549 (0.007)	0.706 (0.006)	0.536 (0.005)
SCL (proposed)	0.696 (0.010)	0.525 (0.008)	0.683 (0.002)	0.524 (0.002)	0.726 (0.003)	0.553 (0.002)	0.730 (0.007)	0.555 (0.007)	0.709 (0.006)	0.539 (0.005)