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. 2026 Jun 17;14:e21449. doi: 10.7717/peerj.21449

Table 2. Comparative analysis of demographic, clinical, and biomarker variables between early and late-stage colorectal cancer patients.

Characteristics Early Late P value
n 245 174
Age, median (IQR) 58 (45, 73) 57.5 (46, 75.75) 0.845
Gender, n (%) 0.395
Female 115 (27.4%) 89 (21.2%)
Male 130 (31%) 85 (20.3%)
Family_History, n (%) 0.271
Yes 119 (28.4%) 94 (22.4%)
No 126 (30.1%) 80 (19.1%)
Smoking, n (%) 0.149
Yes 112 (26.7%) 92 (22%)
No 133 (31.7%) 82 (19.6%)
Alcohol_Consumption, n (%) 0.405
No 134 (32%) 88 (21%)
Yes 111 (26.5%) 86 (20.5%)
Diet, n (%) 0.556
Balanced 84 (20%) 59 (14.1%)
High-fat 72 (17.2%) 59 (14.1%)
Vegetarian 89 (21.2%) 56 (13.4%)
Symptoms, n (%) 0.149
Yes 112 (26.7%) 92 (22%)
No 133 (31.7%) 82 (19.6%)
Treatment_History, n (%) 0.591
Surgery 64 (15.3%) 48 (11.5%)
Radiation 64 (15.3%) 41 (9.8%)
Chemotherapy 53 (12.6%) 46 (11%)
None 64 (15.3%) 39 (9.3%)
Serum_Ferritin, mean ± sd 147.57 ± 29.771 181.62 ± 28.887 <0.001
CA_19_9, mean ± sd 19.676 ± 5.3808 24.701 ± 5.4809 <0.001
CEA, mean ± sd 3.022 ± 1.0698 3.997 ± 1.0053 <0.001

Notes.

IQR
Interquartile Range, representing the range between the 25th and 75th percentiles
n (%)
Number and percentage of patients in each category
P value
Statistical significance, with values less than 0.05 indicating significant differences between early and late-stage groups
sd
Standard deviation, indicating the variability around the mean value of biomarkers