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. Author manuscript; available in PMC: 2026 Jun 23.
Published in final edited form as: J Nat Prod. 2025 Dec 11;88(12):3050–3064. doi: 10.1021/acs.jnatprod.5c01251

Table 3. Sulfur-containing lipids and PKs with signaling activities.

The bolded compounds are highlighted throughout the section and in Figure 6.

Compound(s) Class Sulfur-containing Group(s) Species Activity Reference(s)
Prunomarin A (40) PK Sulfoxide Phomopsis prunorum (F4–3) Anti-NO production 108
Neosartyrone (41) PK Methylsulfonate Neosartorya udagawae HDN13–313 Anti-lipid accumulation 109
Rubterolone N (42) PK Thiazolidine Actinomadura sp. 5–2 Anti-mPGES1 110
Oxazolismycin (43) PK-NRP Methylthiol Streptomyces griseochromogenes ATCC 14511 Anti-ACE 111
Paraphaeospharides (44, 45) PK-NRP Thioether, Sulfoxide Paraphaeosphaeria negelcta FT462 Anti-NFκB, anti-iNOS 113
Dipenirestone A (46) PK Disulfde Penicillium sp. Anti-PI3K, anti-Akt, anti-mTORC1 107
Sulfobacins (47, 48) Lipid Sulfonate Chryseobacterium gleum DSM16776, Alistipes timonensis DSM27924 LPS displacement from TLR4 114–116
Sulfolipid-1 (49) Lipid Sulfate Mycobacterium tuberculosis Erdman TVRP1 agonist 117