Table 3.

Changes in biochemical parameters over time

	Groups
Parameters & Time	Mechanical Debridement	Diode Laser	Combined	P value
PISF
Baseline	1.33 ± 0.65	1.16 ± 0.62	1.33 ± 0.55	0.672
4th week	1.20 ± 0.57	0.97 ± 0.66 a)	0.87 ± 0.50 a)	0.345
12th week	0.79 ± 0.38a), b)	0.55 ± 0.43a), b)	0.56 ± 0.34a), b)	0.256
P value	0.000	0.000	0.000
S100A8 (ng)
Baseline	4.51 ± 0.52	4.78 ± 0.37	4.63 ± 0.47	0.189
4th week	4.29 ± 0.44	4.63 ± 0.34	4.46 ± 0.45	0.134
12th week	4.41 ± 0.37	4.59 ± 0.36	4.38 ± 0.24	0.352
P value	0,872	0,133	0,689

PISF; Peri−implant sulcus fluid

a), significant differences from baseline

b), significant differences from 4th week