Table 1.

Representative Clinical Studies Evaluating Rectus Sheath Block in Laparoscopic Cholecystectomy

Study	Design	Sample Size	Intervention	Comparator	Main Findings
Aboelsuod et al20	RCT	80	Bilateral RSB	Intraperitoneal + wound infiltration	Reduced morphine requirements
Kamei et al27	RCT	75	Bilateral RSB in SILC	SILC or standard LC	Lower early postoperative pain
Fu et al28	Dose-finding study	24	Bilateral RSB	None	Defined ED50 and ED95 for ropivacaine
Fu et al29	RCT	58	RSB + butorphanol	RSB + sufentanil	Lower visceral pain and PONV
Jeong et al33	RCT	200	Preoperative RSB	Postoperative RSB	Lower opioid consumption
Gupta et al34	RCT	75	Bilateral RSB	Intraperitoneal LA or control	Lowest opioid use and pain scores
Saxena et al35	RCT	80	Bilateral RSB + subcostal TAP block	Port-site infiltration	Lower opioid consumption and pain scores
Kitamura et al36	RCT	62	Bilateral RSB	Umbilical infiltration	No significant differences
Wu et al37	RCT	180	TAPB + RSB	TAPB or infiltration	Similar pain outcomes
Izwan et al38	RCT	138	TAP + RSB	Port-site infiltration	Lower opioid consumption
Kim et al39	RCT	40	Bilateral RSB	Control	Reduced early postoperative pain
Selvi et al40	Retrospective	67	SIPB + bilateral RSB	OSTAP block	Lower tramadol consumption
Yoon et al41	RCT	88	TAP + RSB	Bilateral TAP block	No additional analgesic benefit
Karaarslan et al42	RCT	189	OSTAP + RSB	Control	Lower pain and improved QoR-15
Ramkiran et al43	RCT	61	OSTAP + RSB	OSTAP or infiltration	Lowest tramadol consumption
Mo et al44	RCT	49	EOI + bilateral RSB	TAP + bilateral RSB	Lower opioid use and improved recovery
Gangadhar et al46	RCT	70	EOIB + RSB	Port-site infiltration	Reduced analgesic requirements and pain scores
Manıcı et al47	Retrospective	44	Bilateral RSB	Bilateral ESPB	Similar opioid consumption and pain scores
Marrone et al10	Case report	1	DRSB	None	Feasible with excellent analgesia
Petroni et al52	Case report	1	DRSB	None	Excellent analgesia without additional opioid requirements