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Systemic T. cruzi protection induced by intranasal vaccinationsa
| Immunization protocol | Survival (%)b |
|---|---|
| None | 0/9 (0) |
| Unbiased | 2/7 (29) |
| Type 1 biased | 6/6 (100)* |
| Type 2 biased | 1/8 (13) |
BALB/c mice were immunized as shown in Table 1 and challenged with 5,000 T. cruzi BFT subcutaneously in the base of the tail. Shown are the survival rates 3 months postchallenge.
*, P < 0.05 by Fisher's exact test comparing survival in type 1 immunized and all other groups.
