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. 2026 Jun 12;15(12):922. doi: 10.3390/biology15120922
PCC1 Proanthocyanidin C1
GSE Grape seed extract
NSPCC1 Natural Senolytics PCC1
IL-6 Interleukin-6
TNF-α Tumor Necrosis Factor α
CRP C-reactive protein
HSCs Hematopoietic stem cells
DNA Deoxyribonucleic acid
NF-κB Nuclear Factor Kappa B
SD rats Sprague Dawley rats
Y-Veh Young—Vehicle
O-Veh Old—Vehicle
O-NSPCC1 Old—Natural Senolytics PCC1
TBI Total body irradiation
RBC Red blood cell
HGB Hemoglobin
HCT Hematocrit
GSH Reduced glutathione
GSSG Oxidized glutathione
T-GSH Total glutathione
BM Bone marrow
CD4 Cluster of Differentiation 4
CD8 Cluster of Differentiation 8
B220 B-cell marker 220
CD11b Cluster of Differentiation 11b
Gr-1 Granulocyte-1
TER119 Ter119 antigen
IL-7R Interleukin-7 Receptor
FLT3 Fms-like Tyrosine Kinase 3
CD150 Cluster of Differentiation 150
CD48 Cluster of Differentiation 48
Sca-1 Stem Cell Antigen-1
c-Kit KIT proto-oncogene receptor tyrosine kinase
CD16/32 Cluster of Differentiation 16/32
CD34 Cluster of Differentiation 34
CFU Colony-Forming Unit
BFU-E Burst-Forming Unit—Erythroid
CFU-GM Colony-Forming Unit—Granulocyte/Macrophage
CFU-GEMM Colony-Forming Unit—Granulocyte/Erythrocyte/Macrophage/Megakaryocyte
H&E Hematoxylin and eosin staining
BSA Bovine serum albumin
DAB Diaminobenzidine
LC-MS Liquid chromatography–mass spectrometry
AUC Area under the curve
Cmax Maximum plasma concentration
Tmax The time to maximum concentration
HSPCs Hematopoietic stem and progenitor cells
qPCR Quantitative polymerase chain reaction
CCL2/CCR2 C-C Motif Chemokine Ligand 2/C-C Motif Chemokine Receptor 2
IL-1β Interleukin-1β
TGF-β/Smad3 Transforming Growth Factor-beta/Smad3
F4/80 EGF-like Module-containing Mucin-like Hormone Receptor-like 1
iNOS Inducible nitric oxide synthase
PCA Principal component analysis
DEGs Differentially expressed genes
KEGG Kyoto Encyclopedia of Genes and Genomes
GO Gene Ontology
MEPs Megakaryocyte–erythroid progenitors
LSKs Lineage-Sca-1+c-Kit+ cells
CLPs Common lymphoid progenitors