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. 2026 Jun 21;18(12):2006. doi: 10.3390/cancers18122006
MSI Microsatellite instability
MMR Mismatch repair
dMMR MMR deficient
pMMR MMR proficient
CRC Colorectal cancer
mCRC Metastatic colorectal cancer
ICI Immune checkpoint inhibitor
MS Microsatellite
MSS Microsatellite stable
IHC Immunohistochemistry
PCR Polymerase chain reaction
NGS Next generation sequencing
ct Circulating tumor
ctDNA Circulating tumor DNA
MLH1 MutL Homologue 1
MSH2 MutS Homologue 2
MSH3 MutS Homologue 3
MSH6 MutS Homologue 6
PMS2 Postmeiotic Segregation Increased 2
KRAS V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
NRAS Neuroblastoma RAS viral oncogene homolog
BRAF v-Raf murine sarcoma viral oncogene homolog B1
IQR Interquartile range
OS Overall survival
PFS Progression-free survival
CR Complete response
PR Partial response
SD Stable disease
PD Progressive disease
NE Not evaluable
ORR Overall response rate
DCR Disease control rate
VAF Variant allele frequency
bTMB Blood tumor mutational burden
TF Tumor fraction
CI Confidence interval
HR Hazard ratio
SD Standard deviation
CGP Comprehensive genomic profiling