AAV	Adeno-associated virus
BBB	Blood–brain barrier
CNS	Central nervous system
CRISPR	Clustered Regularly Interspaced Short Palindromic Repeats
sgRNA	Single-guide RNA
MELAS	Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes
MERRE	Myoclonic Epilepsy with Ragged Red Fibers
mtDNA	Mitochondrial DNA
MTS	Mitochondria targeting signal
PAM	Protospacer adjacent motif
NARP	Neurogenic muscle weakness, ataxia, and retinitis pigmentosa
lncRNA	Long non-coding RNA
LHON	Leber hereditary optic neuropathy
TALEN	Transcription Activator-Like Effector Nucleases
rAAV	Recombinant Adeno-associated virus
RIC	RNA Import Complex
OxPhos	Oxidative phosphorylation
ZFN	Zinc-finger nucleases
UTR	Untranslated Regions