TABLE 2.
Virulence of CP9 (wild type) and CP82 in a mouse urinary tract infection modellegend
| Specimen and infecting strain | Median CFU/g or CFU/mla | No. of samples (%) for which concn of strain exceeded that of the other:
|
||
|---|---|---|---|---|
| >1-fold | >3-fold | ≥10-fold | ||
| Bladder (n = 48) | ||||
| CP9 | 1.3 × 104 | 41 (85) | 22 (46) | 6 (13) |
| CP82 | 4.0 × 103b | 7 (15)f | 3 (6)f | 1 (2)h |
| Urine (n = 44)c | ||||
| CP9 | 2.0 × 104 | 32 (73) | 23 (52) | 17 (39) |
| CP82 | 6.1 × 103 | 11 (25)f | 6 (14)f | 4 (9)f |
| Kidney (n = 48) | ||||
| CP9 | 5.3 × 101 | 25 (52) | 20 (42) | 17 (35) |
| CP82 | 2.8 × 101e | 10 (21)g | 7 (15)g | 6 (13)i |
a
Data were corrected for input ratios prior to statistical analysis.
b
P = 0.0001 (Wilcoxon rank sum test).
c
Urine specimens could not be obtained from four animals.
legend
dP = 0.0004 (Wilcoxon rank sum test).
e
P = 0.109 (Wilcoxon rank sum test).
f
P < 0.01 (McNemar's test).
g
P < 0.02 (McNemar's test).
h
Not significant (McNemar's test).
i
P < 0.05 (McNemar's test).