TABLE 3.
In vitro growth inhibition activities of sera raised in rabbits against recombinant PpAMA1 FVO and PpAMA1 3D7
Immunogen and rabbit | % Inhibition of parasite clone:
|
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
FVO
|
3D7
|
HB3
|
|||||||||
% Serum
|
% Serum
|
% Serum
|
|||||||||
50 | 37.5 | 25 | 12.5 | 50 | 37.5 | 25 | 12.5 | 50 | 25 | 12.5 | |
PpAMA1 FVO | |||||||||||
R85508 | 76.3 | 71.0 | 67.0 | 50.4 | 27.5 | 17.9 | 0.0 | 2.0 | 39.4 | 32.4 | 22.3 |
R85511 | 76.8 | 76.1 | 73.9 | 62.0 | 51.9 | 44.2 | 33.0 | 18.4 | 72.5 | 61.5 | 54.4 |
R85506 | 39.1 | 37.6 | 37.9 | 28.6 | 0.0 | 0.0 | 0.0 | 0.0 | 27.2 | 17.3 | 7.3 |
R85516 | 69.8 | 66.9 | 58.4 | 40.6 | 26.9 | 16.3 | 10.0 | 9.9 | 43.8 | 35.0 | 19.5 |
R85514 | 67.1 | 62.6 | 49.9 | 33.0 | 35.8 | 27.1 | 16.7 | 12.8 | 52.6 | 41.9 | 24.6 |
Mean | 65.8 | 62.8 | 57.4 | 42.9 | 28.4 | 21.1 | 11.9 | 8.6 | 47.1 | 37.6 | 25.6 |
PpAMA1 3D7 | |||||||||||
R85507 | 0.0 | 0.0 | 0.0 | 0.0 | 51.9 | 38.3 | 22.9 | 4.4 | 6.8 | 0.0 | 0.0 |
R85509 | 26.5 | 26.5 | 23.9 | 11.5 | 97.7 | 95.5 | 88.7 | 62.1 | 53.2 | 38.4 | 29.6 |
R85510 | 15.9 | 13.5 | 8.5 | 0.0 | 85.8 | 77.8 | 68.0 | 44.7 | 42.2 | 29.8 | 18.8 |
R85515 | 69.9 | 67.1 | 56.3 | 40.5 | 96.4 | 91.0 | 82.6 | 51.4 | 62.3 | 45.6 | 24.5 |
R85517 | 27.6 | 23.4 | 19.2 | 1.6 | 88.0 | 82.3 | 72.0 | 50.0 | 40.8 | 39.1 | 25.6 |
Mean | 28.0 | 26.1 | 21.6 | 10.7 | 83.9 | 77.0 | 66.9 | 42.5 | 41.1 | 30.6 | 19.7 |