Table 1.
Loss of liver weight and metabolic acidosis after ethylene glycol (EG) administration
| Control | EG2 | EG5 | |
|---|---|---|---|
| Body Weight (g) | 289.5 ± 12.2 | 265.7 ± 10.5 | 281.7 ± 9.6 |
| Liver Weight (g) | 12.87 ± 0.98 | 12.59 ± 0.70 **** (vs EG5) | 7.80 ± 0.22 **** (vs Control) |
| pH | 7.573 ± 0.162 | 6.942 ± 0.083 ** (vs Control) | 6.878 ± 0.183 ** (vs Control) |
| HCO3− (mmol/L) | 19.93 ± 5.75 | 12.73 ± 3.70 | 10.80 ± 3.32 |
| AG (mEq/L) | 26.40 ± 6.43 | 44.60 ± 2.36 | 48.20 ± 12.47 * (vs Control) |
| AST (IU/L) | 94.4 ± 23.6 | 363.5 ± 257.1 * (vs Control) | 231.8 ± 33.6 |
| ALT (IU/L) | 26.6 ± 1.7 | 82.8 ± 28.8 ** (vs Control) | 44.8 ± 8.4 * (vs EG2) |
| LDH (IFCC) (IU/L) | 214.6 ± 96.7 | 2172.8 ± 1051.4 ** (vs Control) | 1461.5 ± 259.6 * (vs Control) |
After 12 h of fasting, 8-week-old male Wistar rats received a single oral dose of 8 g/kg EG or an equal volume of saline (0.9% NaCl) and were euthanized 2 or 5 days later. Whole body and liver weights 2 and 5 days after EG administration and blood sample analysis. Sample sizes were as follows: body weight and liver weight, n = 6 per group; pH, HCO3−, and AG, n = 3 per group; AST, ALT, and LDH, Control (n = 5), EG2 (n = 4), and EG5 (n = 4). The means ± S.D. are shown. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. AG, anion gap