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. 2026 Jun 16;16(6):421. doi: 10.3390/metabo16060421
α-SMA Alpha-smooth muscle actin
ALI Acute lung injury
ASMase Acid sphingomyelinase
BAL Bronchoalveolar lavage
C1P Ceramide 1-phosphate
CerS Ceramide synthase
CF Cystic fibrosis
CFTR Cystic fibrosis transmembrane conductance regulator
COPD Chronic obstructive pulmonary disease
COVID-19 Coronavirus disease 2019
DEGS Dihydroceramide desaturase
DHS1P Dihydrosphingosine-1-phosphate
ECM Extracellular matrix
EMT Epithelial–mesenchymal transition
EV Extracellular vesicle
HRCT High-resolution computed tomography
IPF Idiopathic pulmonary fibrosis
KDSR 3-ketodihydrosphingosine reductase
LPS Lipopolysaccharide
mtROS Mitochondrial reactive oxygen species
NAC N-acetylcysteine
NF-κB Nuclear factor kappa B
NLRP3 NLR family pyrin domain containing 3
nSMase Neutral sphingomyelinase
PMVEC Pulmonary microvascular endothelial cell
ROS Reactive oxygen species
S1P Sphingosine-1-phosphate
S1PL S1P lyase
S1PR S1P receptor
SphK Sphingosine kinase
SPT Serine palmitoyltransferase
TGF-β Transforming growth factor-beta
TLR Toll-like receptor
TNF-α Tumor necrosis factor-alpha