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. 2026 May 23;19(6):819. doi: 10.3390/ph19060819
ZZCD Zhizi Chi Decoction
CRS Chronic-restraint-stress
PCA Protocatechuic acid
MDD Major Depressive Disorder
IL-1β Interleukin-1beta
IL-6 Interleukin-6
IL-10 Interleukin-10
IL-18 Interleukin-18
TNF-α tumor necrosis factor alpha
TGF-β Transforming growth factor (TGF)-beta
iNOS inducible nitric oxide synthase
Arg-1 Arginase-1
HPC Hippocampus
NLRP3 NLR Family Pyrin Domain Containing 3
BDNF Brain-derived neurotrophic factor
MGB Microbiota–gut–brain
UHPLC-Q-TOF/MS Ultrahigh-performance liquid chromatography–quadrupole time-of-flight tandem mass spectrometry
SCFA Short-chain fatty acid
SPT Sucrose preference test
OFT Open field test
LDB Light–dark box test
EPM Elevated plus maze test
ELISA Enzyme-linked immunosorbent assay
Flx Fluoxetine
AMPK AMP-activated protein kinase
PI3K Phosphatidylinositol 3-kinase
p-PI3K Phosphorylation Phosphatidylinositol 3-kinase
mTOR mammalian target of the rapamycin
p-mTOR Phosphorylation of mammalian target of the rapamycin
ULK1 Unc-51-like autophagy activating kinase 1