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. 2026 Jun 12;19(6):927. doi: 10.3390/ph19060927
Bax Bcl-2-associated X protein
Caspase-1 Cysteine-aspartic acid protease 1
CDNs Cyclic dinucleotides
cGAMP Cyclic guanosine monophosphate-adenosine monophosphate
cGAS Cyclic guanosine monophosphate synthase
CHOP C/EBP homologous protein
CTT C-terminal tail
DAMPs Damage-associated molecular patterns
DN Diabetic nephropathy
dsDNA Double-stranded DNA
ECM Extracellular matrix
EMT Epithelial–mesenchymal transition
ER Endoplasmic reticulum
ERS Endoplasmic reticulum stress
ESRD End-stage renal disease
EVs Extracellular vesicles
FASN Fatty acid synthetase
GFR Glomerular filtration rate
GLP-1 Glucagon-like peptide-1
GMCs Glomerular mesangial cells
GSDMD Gasdermin D
HG High glucose
HMGB1 High mobility group protein 1
hPSCs Human pluripotent stem cells
IDI1 Isopentenyl diphosphate isomerase 1
IFN Interferon
IKK I kappa B kinase
IL Interleukin
iPSCs Induced pluripotent stem cells
IRF Interferon regulatory factor
LBD Ligand-binding domain
MCP-1 Monocyte Chemoattractant Protein-1
mtDNA Mitochondrial DNA
NF-κB Nuclear factor kappa-B
NLRP3 NOD-like receptor thermal protein domain associated protein 3
PCSK9 Protease-kexin 9
PPP6C Protein phosphatase 6
RAAS Renin–angiotensin–aldosterone system
RIPK Receptor interaction protein kinase
RNAi RNA interference
ROS Reactive oxygen species
SGLT2 Sodium-dependent glucose transporters 2
STING Stimulator of interferon genes
TBK1 TANK-binding kinase 1
TBK1 TANK binding kinase 1
TGF-β Transforming growth factor-β
TNF-α Tumor necrosis factor-α
TRIM Tripartite motif containing