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. 2026 May 27;18(6):654. doi: 10.3390/pharmaceutics18060654
AUC Area under the curve
BMI Body mass index
BW Body weight
Cl/F Apparent clearance
Cmax Maximum plasma concentration
eGFR Estimated glomerular filtration rate
GOF Goodness of fit
HbF Fetal hemoglobin
HU Hydroxyurea
IIV Interindividual variability
IWRES Individual weighted residual
ka Absorbance rate constant
LRT Likelihood ratio test
MCV Mean corpuscular volume
MTD Maximum tolerated dose
NBW Normalized body weight
NCA Non-compartmental analysis
NPDE Normalized prediction distribution error
OFV Objective function value
pcVPC Prediction-corrected visual predictive check
PD Pharmacodynamics
PK Pharmacokinetics
RSE Relative standard error
SCD Sickle cell disease
Tmax Time to reach the maximum plasma concentration
Vd/F Apparent volume of distribution