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. 2026 May 29;18(6):680. doi: 10.3390/pharmaceutics18060680
AUCinf Area under the plasma concentration–time curve extrapolated to infinity
AUClast Area under the plasma concentration–time curve to the last measurable concentration
BE Bioequivalence
BQL Below the quantification limit
Caco-2 Human colorectal adenocarcinoma cell line (Caco-2)
C10 Sodium caprate
C max Maximum plasma concentration
DLS Dynamic light scattering
DW Distilled water
D 10 Particle diameter at 10% of the cumulative distribution
D 50 Particle diameter at 50% of the cumulative distribution
D 90 Particle diameter at 90% of the cumulative distribution
EMA European Medicines Agency
FDA Food and Drug Administration
f 2 Similarity factor
GI Gastrointestinal
GLP-1 RA Glucagon-like peptide-1 receptor agonist
HCl Hydrochloric acid
HPLC High-performance liquid chromatography
IACUC Institutional Animal Care and Use Committee
IR Immediate-release
K2-EDTA Dipotassium ethylenediaminetetraacetic acid
k el Terminal elimination rate constant
LC–MS/MS Liquid chromatography–tandem mass spectrometry
LDH Lactate dehydrogenase
LLOQ Lower limit of quantification
LSD Least significant difference
MCC Microcrystalline cellulose
MCFA Medium-chain fatty acid
MFDS Ministry of Food and Drug Safety
MRM Multiple-reaction monitoring
MTT 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
NCA Non-compartmental analysis
OM Optical microscopy
Papp Apparent permeability coefficient
PDI Polydispersity index
PK Pharmacokinetic(s)
QbD Quality by design
SBL-T Semaglutide bilayer tablet
SCC-T Semaglutide compression-coated tablet
SD Standard deviation
SNAC Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate
SSL-T Semaglutide single-layer tablet
t ½ Elimination half-life
t max Time to maximum plasma concentration
TEER Transepithelial electrical resistance
USP United States Pharmacopeia