TABLE 2.
Protective immunity induced by recombinant Salmonella
| Immunizing strain | CFU (mean ± SD) of Listeria in spleens of 8 mice/group | No. of mice containing Listeria in spleens/total no. of mice |
|---|---|---|
| sv1/2a EGD | 0a | 0/8 |
| SB824 | (2.3 ± 3.6) × 105 | 8/8 |
| SB824(pHR231) | (2.6 ± 1.5) × 102 | 8/8 |
| SB824(pHR241) | (2.6 ± 2.9) × 102 | 8/8 |
| SB824(pHR251) | (1.4 ± 1.5) × 101b | 5/8 |
a
No bacteria were detected in spleens of eight mice that had received a sublethal intraperitoneal dose of 5 × 103 CFU of Listeria 8 weeks before the challenge infection.
b
Value differs significantly from those of mice immunized with SB824(pHR231) or SB824(pHR241) (P < 0.05).