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Cas-1-deficient mice are more susceptible to infectiona
| Background | Genotype | LD50 (CFU) of E. coli |
|---|---|---|
| C3H/HeN | Wild type | 13,700 |
| C3H/HeN | cas-1+/− | 13,100 |
| C3H/HeN | cas-1−/− | 3,860 |
Mice were infected with different doses of E. coli O18:K1:H7 strain (Bort) i.p. and observed for mortality for 48 h. The percent mortality was plotted against the dose of E. coli (Bort), and the LD50 was calculated from sigmoidal dose-response analysis by using GraphPad Prizm software.
