. Author manuscript; available in PMC: 2026 Jun 28.

Published in final edited form as: Mater Sci Eng C Mater Biol Appl. 2020 Sep 23;118:111536. doi: 10.1016/j.msec.2020.111536

Table 2.

Classification of redox-sensitive nanoplatforms

Nanocarrier	Chemical backbone structure	Ref
Liposomal nanoparticles	Disulfide conjugates of PEG and phospholipids	(39–46)
Polymeric micelles	Synthetic polymers: Hydrophobic: polyester (PCL, PGA, PLA, PLGA) Hydrophilic: polyether, polyamide (PEG, PNIPAM) Biopolymers: Polysaccharide: Hyaluronic acid, Chitosan, Heparin, and Chondroitin sulfate	(1, 25, 31, 47–61)
Polyplex nanoparticles	Cationic polyamine (PEI)	(11, 62–66)
Inorganic nanoparticles (macromolecule structure of inorganic elements such as Si, Mn, Fe, Au, Ag)	Functionalized by organic groups and polymer such as OH, COOH, PEG, PLGA, PEI Functionalized by polysaccharide (cyclodextrin, Hyaluronic acid) and peptide	(67–82)
Nanogels/Hydrogel	Synthetic polymers: Polyether, polyamide (PEG, PNIPAM) Biopolymers: Polysaccharide, Hyaluronic acid	(21, 32, 57, 83, 84)