Table 7.

Advantages and disadvantages of redox-sensitive nanocarrier

Carrier	Advantages	Disadvantages
Polymeric micelles	Improvement solubility of hydrophobic drug and pharmacokinetic barriers/ targeted delivery/ controlling drug release/	Low drug loading capacity/ application only for hydrophobic drug /dependency for critical micelle concentration
Polyplex nanoparticles	High stability in extracellular and low stability in intracellular media/ High loading capacity of hydrophobic and ionic drugs, DNA, RNA /targeted delivery/	Cellular toxicity/ limited delivery of hydrophilic active agents high cost
Nanogels/Hydrogel	High drug loading capacity/ rapidly release anticancer drug /Delivery of hydrophobic, hydrophilic and ionic drug/ high permeation capability due to small size.	Expensive methods for removing solvent and surfactant. Side effect due to remaining surfactant or monomer.
Inorganic nanoparticle	Additional property such as mechanical, optical, thermal, electrical/ high surface area/	Dependency to functionalization process/ cellular toxicity