Table 2.
Systolic blood pressure and clinical outcomes
| Univariate | Multivariate | |||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| All-cause mortality | ||||
| VL-sys | 0.83 (0.69–1.00) | 0.051 | 1.12 (0.93–1.36) | 0.237 |
| L-sys | 0.82 (0.77–0.87) | < 0.001 | 0.92 (0.86–0.99) | 0.016 |
| H-sys | 1.09 (1.06–1.12) | < 0.001 | 1.10 (1.07–1.14) | < 0.001 |
| VH-sys | 1.30 (1.24–1.35) | < 0.001 | 1.33 (1.28–1.39) | < 0.001 |
| EH-sys | 1.34 (1.21–1.48) | < 0.001 | 1.47 (1.33–1.63) | < 0.001 |
| CVE | ||||
| VL-sys | 0.56 (0.41–0.78) | < 0.001 | 0.76 (0.55–1.06) | 0.111 |
| L-sys | 0.72 (0.65–0.79) | < 0.001 | 0.84 (0.76–0.93) | < 0.001 |
| H-sys | 1.14 (1.09–1.19) | < 0.001 | 1.11 (1.06–1.15) | < 0.001 |
| VH-sys | 1.40 (1.32–1.49) | < 0.001 | 1.32 (1.24–1.41) | < 0.001 |
| EH-sys | 1.30 (1.11–1.52) | < 0.001 | 1.21 (1.04–1.42) | 0.016 |
| Afib | ||||
| VL-sys | 0.90 (0.66–1.23) | 0.509 | 1.01 (0.74–1.39) | 0.943 |
| L-sys | 0.75 (0.67–0.84) | < 0.001 | 0.83 (0.74–0.93) | 0.002 |
| H-sys | 1.02 (0.97–1.07) | 0.395 | 1.00 (0.95–1.05) | 0.910 |
| VH-sys | 1.12 (1.04–1.20) | 0.003 | 1.09 (1.01–1.17) | 0.029 |
| EH-sys | 1.19 (1.00–1.42) | 0.046 | 1.21 (1.01–1.44) | 0.036 |
| Dementia | ||||
| VL-sys | 0.80 (0.52–1.25) | 0.331 | 1.04 (0.67–1.63) | 0.853 |
| L-sys | 0.94 (0.82–1.08) | 0.371 | 1.01 (0.88–1.16) | 0.870 |
| H-sys | 1.06 (0.99–1.13) | 0.066 | 1.11 (1.04–1.18) | 0.002 |
| VH-sys | 1.12 (1.02–1.24) | 0.021 | 1.20 (1.08–1.32) | < 0.001 |
| EH-sys | 1.23 (0.98–1.55) | 0.077 | 1.39 (1.10–1.75) | 0.006 |
| Fracture | ||||
| VL-sys | 0.99 (0.77–1.28) | 0.952 | 0.99 (0.76–1.27) | 0.913 |
| L-sys | 1.04 (0.96–1.13) | 0.376 | 1.04 (0.96–1.14) | 0.332 |
| H-sys | 1.03 (0.99–1.08) | 0.103 | 1.06 (1.02–1.11) | 0.005 |
| VH-sys | 1.11 (1.04–1.18) | < 0.001 | 1.14 (1.07–1.22) | < 0.001 |
| EH-sys | 1.25 (1.08–1.45) | 0.003 | 1.30 (1.12–1.51) | < 0.001 |
Multivariate analysis was adjusted for age, sex, vascular access type, hemodialysis vintage, underlying cause of end-stage kidney disease, Charlson Comorbidity Index score, Kt/Vurea, ultrafiltration volume, hemoglobin, serum albumin, serum creatinine, serum phosphorus, serum calcium, use of antihypertensive drugs, statins, clopidogrel or aspirin, the presence of myocardial infarction or congestive heart failure, and cerebrovascular events. The analysis was performed using the enter method. The reference group consisted of patients with 120 ≤ systolic blood pressure < 140 mmHg
Abbreviations: Afib, atrial fibrillation; CI, confidence interval; CVE, cardiovascular event; HR, hazard ratio; SBP, systolic blood pressure. SBP categories: EH-sys, SBP ≥ 180 mmHg; H-sys, 140 ≤ SBP < 160 mmHg; L-sys, 100 mmHg ≤ SBP < 120 mmHg; VH-sys, 160 ≤ SBP < 180 mmHg; VL-sys, SBP < 100 mmHg