Table 3.
Diastolic blood pressure and clinical outcomes
| Univariate | Multivariate | |||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| All-cause mortality | ||||
| EL-dia | 1.71 (1.60–1.83) | < 0.001 | 0.96 (0.89–1.02) | 0.193 |
| VL-dia | 1.37 (1.32–1.42) | < 0.001 | 0.89 (0.86–0.93) | < 0.001 |
| L-dia | 1.09 (1.06–1.12) | < 0.001 | 0.93 (0.90–0.96) | < 0.001 |
| H-dia | 0.92 (0.88–0.97) | 0.001 | 1.12 (1.06–1.17) | < 0.001 |
| VH-dia | 0.69 (0.60–0.81) | < 0.001 | 1.19 (1.02–1.38) | 0.029 |
| CVE | ||||
| EL-dia | 1.15 (1.02–1.29) | 0.024 | 0.82 (0.73–0.93) | 0.002 |
| VL-dia | 1.17 (1.10–1.24) | < 0.001 | 0.91 (0.86–0.97) | 0.005 |
| L-dia | 0.98 (0.94–1.03) | 0.446 | 0.90 (0.86–0.94) | < 0.001 |
| H-dia | 0.99 (0.93–1.06) | 0.760 | 1.08 (1.01–1.16) | 0.019 |
| VH-dia | 0.92 (0.76–1.11) | 0.386 | 1.23 (1.01–1.48) | 0.035 |
| Afib | ||||
| EL-dia | 1.37 (1.20–1.54) | < 0.001 | 1.07 (0.94–1.22) | 0.289 |
| VL-dia | 1.23 (1.15–1.32) | < 0.001 | 1.03 (0.96–1.10) | 0.440 |
| L-dia | 1.06 (1.01–1.12) | 0.021 | 1.01 (0.96–1.06) | 0.732 |
| H-dia | 0.97 (0.89–1.05) | 0.381 | 1.05 (0.97–1.14) | 0.215 |
| VH-dia | 0.90 (0.72–1.13) | 0.362 | 1.19 (0.94–1.50) | 0.140 |
| Dementia | ||||
| EL-dia | 1.16 (0.97–1.38) | 0.100 | 0.66 (0.55–0.78) | < 0.001 |
| VL-dia | 1.29 (1.18–1.41) | < 0.001 | 0.84 (0.77–0.92) | < 0.001 |
| L-dia | 1.05 (0.98–1.13) | 0.131 | 0.89 (0.83–0.96) | 0.001 |
| H-dia | 0.91 (0.81–1.01) | 0.068 | 1.11 (1.00–1.24) | 0.049 |
| VH-dia | 0.66 (0.47–0.93) | 0.017 | 1.13 (0.80–1.59) | 0.490 |
| Fracture | ||||
| EL-dia | 1.59 (1.44–1.75) | < 0.001 | 1.08 (0.98–1.19) | 0.134 |
| VL-dia | 1.31 (1.24–1.39) | < 0.001 | 0.99 (0.93–1.05) | 0.665 |
| L-dia | 1.10 (1.05–1.15) | < 0.001 | 0.98 (0.94–1.03) | 0.462 |
| H-dia | 0.91 (0.85–0.97) | 0.007 | 1.03 (0.96–1.10) | 0.418 |
| VH-dia | 0.74 (0.60–0.91) | 0.004 | 1.01 (0.82–1.25) | 0.892 |
Multivariate analysis was adjusted for age, sex, vascular access type, hemodialysis vintage, underlying cause of end-stage kidney disease, Charlson Comorbidity Index score, Kt/Vurea, ultrafiltration volume, hemoglobin, serum albumin, serum creatinine, serum phosphorus, serum calcium, use of antihypertensive drugs, statins, clopidogrel, or aspirin, the presence of myocardial infarction or congestive heart failure, and cerebrovascular events. The anlaysis was performed using the enter method. The reference group consisted of patients with 80 ≤ diastolic blood pressure < 90 mmHg
Abbreviations: Afib, atrial fibrillation; CI, confidence interval, CVE, cardiovascular event; DBP, diastolic blood pressure; HR, hazard ratio. DBP categories: EL-dia, DBP < 60 mmHg; H-dia, 90 ≤ DBP < 100 mmHg; L-dia, 70 ≤ DBP < 80 mmHg; VH-dia, DBP ≥ 100 mmHg; VL-dia, 60 ≤ DBP < 70 mmHg