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. 2026 Apr 23;17:5648. doi: 10.1038/s41467-026-72203-3

Fig. 6. CD34/LNP-CAR mRNA treatment repairs the intima injury and protects the aortic structure.

Fig. 6

a Representative image showing HE, MASSON, and EVG staining for aortic cross-sections. b Data of the collagen positive area and elastin fragmentation. Data in (b) are from n = 5 biologically independent samples. c Permeability of the aortic intimal barrier (to Evans blue dye). d The quantity data of percentage of endothelialization. Data in (d) are from n = 3 biologically independent samples. e Representative SEM imaging. Data in (e) are representative images from two independent experiments. f Representative immunofluorescence of CD34 and CD31 in the aortic sections. g Quantitative analyses of intima CD31 intensity Data in (g) are from n = 3 biologically independent samples. h Quantitative analyses of intima and adventitia CD34 intensity, Data in (h) are from n = 3 biologically independent samples. All data are presented as mean ± s.d. Statistical significance and P-values of (b, d and g) were analyzed by using one-way ANOVA followed by Tukey’s multiple comparisons test (two-sided). Statistical significance and P-values of (h) were analyzed by using two-way ANOVA followed by Tukey’s multiple comparisons test (two-sided). *P < 0.05, **P < 0.01, ***P < 0.001. Scale bars, 200 or 20 μm (a); 20 μm (e); 10 or 20 μm (f). Source data are provided as a Source Data file.