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. 2026 Apr 23;17:5648. doi: 10.1038/s41467-026-72203-3

Fig. 7. Single-cell transcriptomic profiling reveals vascular and immune modulation by CD34/LNP-CAR mRNA therapy.

Fig. 7

a UMAP plot showing all cells isolated from aortic tissues of BAPN-induced mice treated with either saline or CD34/LNP-CAR mRNA for seven days. b Relative proportions of major cell clusters in the aortic samples from the saline and CD34/LNP-CAR mRNA groups. c Violin plots depicting the expression levels of representative marker genes across different cell types. d Cell–cell interaction networks inferred under saline and CD34/LNP-CAR mRNA treatment conditions. e UMAP projection of aortic endothelial cells, color-coded by molecularly defined subtypes, demonstrating compositional differences in endothelial subclusters between saline- and CD34/LNP-CAR mRNA–treated aortic samples, and the relative proportions of each subtype. f GO enrichment analysis of differentially expressed genes within the endothelial cell clusters following CD34/LNP-CAR mRNA treatment. Dot size corresponds to the number of genes; color represents the -log₁₀(P-value). Analysis was performed using the clusterProfiler R package based on a two-sided hypergeometric test, with P-values adjusted for multiple comparisons using the Benjamini-Hochberg (FDR) method. Only terms with an adjusted P < 0.05 are shown. Source data are provided as a Source Data file.