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. Author manuscript; available in PMC: 2026 Jul 1.
Published in final edited form as: Neuroscience. 2026 Jun 9;610:147–162. doi: 10.1016/j.neuroscience.2026.06.002

Fig. 2. Iba1-labeling in the hippocampus from US female and male rats following Oxy CPP.

Fig. 2.

a. Low magnification photomicrograph of Iba1 labeling the dorsal hippocampus. Enlarged boxed regions indicate areas of the CA1(b), CA2/3a (c), CA3b (d) and dentate gyrus (DG; e) that were sampled. Abbreviations: CH, central hilus; GCL, granule cell layer; IGL, infragranular layer of DG; SP, pyramidal cell layer; SLM, stratum lacunosum-moleculare; SGL, supragranular layer of DG; SO, stratum oriens; SLu, stratum lucidum; SR, stratum radiatum; dSR, distal SR; nSR, near SR. f-i. Representative micrographs showing Iba1 labeling in the CA2/3a of US Sal female (f), Oxy female (g), Sal male (h) and Oxy male (i) rats. j. CA2/3a: Oxy females compared to Sal females show higher Iba1 densities in the nSR and dSR. k-n. Representative micrographs showing Iba1 labeling in the CA3b of Sal female (k), Oxy male (l), Sal female (m) and Oxy female (n) rats. o. CA3b: Oxy females compared to Sal females show greater Iba1 densities in SP. Sal males compared to Sal females show higher Iba1 densities in SO and SP. Data are expressed as mean +/− SEM, N = 6 rats/grp. * p < 0.05; ** p < 0.01. Scale Bars: a, 500 microns; b-e, 200 microns; f-i & k-n, 100 microns