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. Author manuscript; available in PMC: 2026 Jul 1.
Published in final edited form as: Neuroscience. 2026 Jun 9;610:147–162. doi: 10.1016/j.neuroscience.2026.06.002

Fig. 5. GFAP-labeling in the hippocampus from US female and male rats following Oxy CPP.

Fig. 5.

a. Low magnification photomicrograph of GFAP labeling the dorsal hippocampus. Enlarged boxed regions indicate areas of the CA1(b), CA2/3a (c), CA3b (d) and dentate gyrus (DG; e) that were sampled. f-i. Representative micrographs showing GFAP labeling in the CA1 of US Sal female (f), Oxy female (g), Sal Male (h), and Oxy male (i) rats. j. CA1: Sal females compared to Sal males showed a higher GFAP densities in SO and SR. Oxy females compared to Sal females had higher GFAP labeling density In SO. In contrast, Oxy males compared to Sal males had lower GFAP densities in the SO, SP, and SR. k-n. Representative micrographs showing GFAP labeling in the CA3b of US Sal female (k), Oxy female (l), Sal male (m), and Oxy male (n) rats. o. CA3b: Oxy females compared to Sal females had higher GFAP densities In SO and SR. Oxy males compared to Sal males had higher GFAP densities in SO, SLu and SR than. p-s. Representative micrographs showing GFAP labeling in the DG of US Sal female (p), Oxy female (q), Sal Male (r), and Oxy male (s) rats. t. DG: Sal females compared to Sal males had a higher GFAP densities in SGL. Oxy females compared to Sal females and Oxy males had lower GFAP densities in the IGL and SGL. Data are expressed as mean +/− SEM, N = 5–6 rats/grp. *p < 0.05, **p<0.01, ***p<0.001, ****p<0.0001. Scale Bars: a, 500 microns; b-e, 200 microns; f-i, k-n, p-s, 100 microns