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. Author manuscript; available in PMC: 2026 Jul 1.
Published in final edited form as: Neuroscience. 2026 Jun 9;610:147–162. doi: 10.1016/j.neuroscience.2026.06.002

Fig. 6. GFAP-labeling in the hippocampus from CIS female and male rats following Oxy CPP.

Fig. 6.

a-d. Representative micrographs showing GFAP labeling in the CA1 of Sal CIS female (a), Oxy CIS female (b), Sal CIS Male (c), and Oxy CIS male (d) rats. e. CA1: Sal CIS females compared to Sal males had higher GFAP labeling densities in SLM. Oxy CIS females compared to Sal CIS females had higher GFAP densities in the SO, SR and SLM. In contrast, Oxy males compared Sal males had lower GFAP densities in SO and SR. Oxy CIS females compared to Oxy CIS males had a higher GFAP densities in the SO, SR and SLM. f-i. Representative micrographs showing GFAP labeling in the CA2/3a of Sal CIS female (f) Oxy CIS female (g), Sal CIS Male (h), and Oxy CIS male (i) rats. j. CA2/3a: Oxy CIS males compared to Sal CIS males and Oxy CIS females had lower GFAP densities in SO. k-n. Representative micrographs showing GFAP labeling in the CA3b of Sal CIS female (k), Oxy CIS female (l), Sal CIS Male (m), and Oxy CIS male (n) rats. o. CA3b: Oxy CIS females compared to Sal CIS females had higher GFAP densities in SR. p-s. Representative micrographs showing GFAP labeling in the DG of Sal CIS female (p), Oxy CIS female (q), Sal CIS male (r), and Oxy CIS male (s) rats. t. DG: Sal CIS females compared to Sal CIS males have a higher GFAP densities in the IGL, CH and SGL. Oxy CIS females compared to Sal CIS females had a lower GFAP labeling densities in the IGL and CH. Conversely, Oxy CIS males compared to Sal CIS males females had higher GFAP densities in the IGL, CH and SGL. Oxy CIS males also had higher GFAP densities in IGL and SGL compared to Oxy CIS females. Data are expressed as mean +/− SEM, N = 5–6 rats/grp. *p < 0.05, **p<0.01, ***p<0.001, ****p<0.0001. Scale Bars: a-d, f-I, k-m & p-s, 100 microns