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[Preprint]. 2026 May 9:2026.05.08.723598. [Version 1] doi: 10.64898/2026.05.08.723598

Figure 2: Structural basis for IgaA recognition of RcsF.

Figure 2:

A) Overall architecture of the IgaAKp/RcsFKp complex from Cryo-EM reconstruction. RcsF is highlighted in gold. B) AlphaFold3 model of IgaA/RcsF fitted into the Cryo-EM density shown in panel (A). C) High-resolution Cryo-EM map of Apo IgaA-bound Fab57 (purple). Mask excluding the detergent micelle was applied to obtain well-resolved features of the periplasmic domain of IgaA. D) Refined structure of IgaAKp/Fab57 complex. E) High-resolution Cryo-EM map of IgaAKp/Fab57/RcsFKp complex. Masking was applied to improve IgaA and RcsF periplasmic features. F) Refined structure of IgaAKp/Fab57/RcsFKp complex. G) Cryo-EM map of full-length IgaAKp in complex with Fab57.