Table 1.
Cases of recipients of kidney allograft after native kidney failure attributed to anti-MPO ANCA associated vasculitis.
| Patients# | Recipient HLA Ags of interest | Donor HLA Ags of interest | Post-transplant anti-MPO testing | Type of transplant | Immunosuppression (induction; maintenance) | Recurrence |
|---|---|---|---|---|---|---|
| 1 | None | None | Negative | Living | Thymoglobulin; tacrolimus, mycophenolic acid | No |
| 2 | None | DR4 | NA | Deceased | Thymoglobulin; tacrolimus, mycophenolic acid | No |
| 3 | DQ7 | DQ7 | Negative | Living) | Basiliximab; tacrolimus, mycophenolic acid | No |
| 4 | None | None | Positive(up to 91 AU/mL) | Living | Thymoglobulin; tacrolimus, mycophenolic acid | No |
| 5 | None | None | Positive(up to 38 AU/mL) | Deceased | Thymoglobulin; rapamycin, mycophenolate mofetil, prednisone | No |
| 6 | DQ9 | DQ9 | Negative | Deceased | Thymoglobulin; tacrolimus, mycophenolic acid | No |
| 7 | DQ7 | DQ7 | Negative | Living | Thymoglobulin; tacrolimus, mycophenolic acid | No |
| 8 | DR4 | DQ7 | NA | Deceased | Thymoglobulin; tacrolimus, mycophenolate mofetil, prednisone (converted to belatacept-based regimen two months post-transplantation) | No |
| 9 | DR4/DQ7 | DR4/DQ7 | Negative | Living | Thymoglobulin; tacrolimus, mycophenolic acid | No |
| 10 | None | None | Negative | Deceased | Thymoglobulin; tacrolimus, mycophenolic acid (converted to belatacept-based regimen five days post-transplantation) | No |
| 11 | DR4/DQ7 | DQ7 | NA | Living) | Thymoglobulin; tacrolimus, mycophenolate mofetil | No |
| 12 | None | DR4 | NA | Deceased | Thymoglobulin; tacrolimus, mycophenolic acid | No |
| 13 | DQ7, DQ9 | None | NA | Deceased | Thymoglobulin; belatacept, mycophenolic acid, prednisone | No |
| Current case | DR4/DQ7 | DR4/DQ7 |
Positive
(>800 AI/mL) |
Deceased | Thymoglobulin; belatacept, mycophenolate sodium, prednisone | Yes |
Ags, antigens.Bold value is used to label the index case, which was the only case developing post-transplant recurrence.