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. 2026 Jun 17;16:1858453. doi: 10.3389/fonc.2026.1858453

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Copyright © 2026 Zhao, Zhao, Liu, Hou, Chen, Lan and Ping.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plot summarizing grade three or higher adverse event incidence for three study arms, displaying events, total participants, proportions, and 95 percent confidence intervals. Combined random effects model shows overall incidence proportion zero point zero eight nine, with confidence interval zero point zero five zero to zero point one five five. Heterogeneity statistics indicate low variability among studies. — Forest plot of the pooled incidence of grade ≥3 adverse events.