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. 2026 Jun 17;16:1858453. doi: 10.3389/fonc.2026.1858453

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Copyright © 2026 Zhao, Zhao, Liu, Hou, Chen, Lan and Ping.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plot showing adverse event incidence proportions from five study arms with 95 percent confidence intervals. Pooled random effects estimate is 0.592 with confidence interval 0.279 to 0.845. Heterogeneity is high at I squared equals 96.6 percent, tau squared equals 1.0700, p less than 0.0001. — Forest plot of the pooled incidence of adverse events of any grade.