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. 2026 Jun 17;5:1840060. doi: 10.3389/frtra.2026.1840060

Figure 1.

Panel A presents a timeline depicting heart transplant in mice, abatacept injection, and graft monitoring by palpation or echocardiography, ending with graft harvest upon confirmed rejection. Panel B displays echocardiogram tracings illustrating stages of graft function: full, declining, and rejection. Panel C shows a survival probability curve comparing Echo (black) and palpation (red) monitoring post-transplant. Panel D features a heat map comparing agreement between Echo and palpation methods, with labeled correlation values.

Reduced variability in delineating graft rejection using echocardiography. (A) Experimental schematic. (B) Representative tracing a full function (left), declining function (middle) and rejection (right). (C) Kaplan–Meier graft survival curves assessed by palpation (P, gray) and echocardiography (Echo, black). Each mouse was evaluated by both modalities. Matching symbols represent survival as determined by the two modalities (n = 6). (D) Pearson coefficient comparing reproducibility of graft rejection determination by the 4 blinded and independent observers (Echo 1, Echo 2, P 1, P 2).