Table 1.
Model variables
| Name | Model compartment | Description (units) |
|---|---|---|
| Bcf | Plasma | Free complex in circulation (# vol−1) |
| Bcb | Plasma | Bound complex in circulation (# vol−1) |
| Ec | Extracellular | Extracellular complex in local vicinity (# vol−1) |
| Enc | Intracellular | Endosomal complex (# vol−1) |
| Enna | Intracellular | Endosomal free siRNA (# vol−1) |
| Cc | Intracellular | Cytoplasmic complex (# vol−1) |
| Cna | Intracellular | Cytoplasmic free siRNA (# vol−1) |
| R | Intracellular | Activated RISC complex (# vol−1) |
| C | Intracellular | Activated RISC complex bound to mRNA (# vol−1) |
| M | Intracellular | Target mRNA (# vol−1) |
| P | Intracellular | Target protein (# vol−1) |
| Z | Intracellular | Number of cells (#) |