Figure 2.

Clinical signs are induced by intramuscular immunization with peptide, but not with DNA. At 8 days after LCMV infection, microchip-implanted C57BL/6 mice received saline alone (filled circles, solid lines) or a vaccine containing both the NP₃₉₆ and the GP₃₃ epitopes (open symbols, dotted lines); the vaccine was either a mixture of plasmids encoding the viral NP and GP (left panel), or the NP₃₉₆ plus GP₃₃ peptide mix (right panel). After injection, their body temperatures were determined every 2 hours.