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. 2006 Jan 19;116(2):465–475. doi: 10.1172/JCI25608

Figure 8.

Figure 8

zVADfmk blocks peptide-induced intestinal apoptosis, but not mucin exocytosis. C57BL/6 mice at 8 days postinfection were injected with either peptide or saline. Some mice from each group were treated with zVADfmk, as described in the text. (A–D) DAPI staining (blue) was used to identify cell nuclei; B–D are overexposed to allow the villus outlines to be visualized. (A) Anti-CD3 staining (green) reveals T cells in the intestinal villi. B–D were stained using the ApopTag kit; apoptotic cells contain red nuclei. Mice had received (B) saline, (C) peptide, or (D) peptide and zVADfmk. (E–G) PAS-stained jejunums from mice that had received (E) saline, (F) peptide, or (G) peptide plus zVADfmk. Magnification, ×40 (A), ×20 (B–G).