Figure 9.

zVADfmk has no effect on hypothermia but protects against lethal outcome. (A) Sixteen C57BL/6 mice were implanted with IPTT-100 temperature probes 2 days before they were infected with LCMV. Eight days after infection, 8 mice were injected with 1 mg of zVADfmk. An hour later, 7 mice from each group were injected with peptide, while 1 mouse was injected with saline, and body temperatures were monitored over the next 24 hours. (B) A diagrammatic summary of the effects of peptide injection of virus-immune mice. The cell at the top left represents any MHC class I⁺ somatic cell. m, membrane TNF; s, soluble TNF.