Fig. 3.

Long-term DNP intervention effects on body weight, physiological manifestations, and nasopharyngeal ¹⁸F-FDG uptake. (A) Weight changes in each group after long-term intervention. n = 16 (DNP), n = 8 (DMSO), n = 8 (Control) at baseline, n = 8 (DNP), n = 6 (DMSO), n = 5 (Control) at the endpoint. (B) The body shape of the animals in the control group at the end of the experiment was not significantly different from that at the beginning of the experiment. (C) The animals in the DNP group at the scheduled endpoint were skinny, with sparse and lackluster hair, and exhibited nasal discharge. (D) ¹⁸F-FDG microPET/CT imaging results revealed almost no nasopharyngeal uptake of ¹⁸F-FDG in the DMSO group or the control group but significant nasopharyngeal uptake in the DNP group