Table 6.
Resistance genes and mutation sites of different drug-resistant strains (N = 45).
| Resistance genes and mutation sites | Number of detections |
|---|---|
| Single gene mutations | |
| rpoB526 | 1 |
| rpoB531 | 2 |
| rpoB533 | 1 |
| katG315 | 2 |
| rpsL43 | 1 |
| pncA156 | 1 |
| Dual gene mutations | |
| rpoB531+katG315 | 1 |
| rpoB526+katG315 | 1 |
| rpoB533+katG393 | 1 |
| rpoB457+katG397 | 1 |
| rpoB531+katG343 | 1 |
| rpoB513+katG315 | 1 |
| rpoB531+ahpC | 1 |
| rpoB512+rpsL43 | 1 |
| rpoB526+embB306 | 1 |
| rpoB450+gyrA94 | 1 |
| rpoB531+gyrA90 | 1 |
| Triple gene mutations | |
| rpoB511+katG315+embB306 | 1 |
| rpoB513+katG315+rpsL43 | 1 |
| rpoB514+katG315+rpsL43 | 1 |
| rpoB526+katG315+rpsL43 | 2 |
| rpoB531+katG315+rpsL43 | 2 |
| rpoB531+katG397+embB311 | 1 |
| rpoB531+embB306+rpsL43 | 1 |
| Quadruple gene mutations | |
| rpoB507+katG234+embB318+pncA159 | 1 |
| rpoB512+katG234+embB297+pncA159 | 1 |
| rpoB526+katG315+rpsL526+pncA43 | 1 |
| rpoB531+katG315+rpsL43+pncA97 | 1 |
| rpoB531+katG315+rpsL46+pncA132 | 1 |
| rpoB531+katG315+rpsL43+rrs | 1 |
| rpoB531+katG315+embB306+pncA131 | 1 |
| rpoB513+embB406+gyrA90+rpsL88 | 1 |
| Multiple gene mutations (≥5 genes) | |
| rpoB531+katG315+embB306+rpsL43+pncA47 | 1 |
| rpoB531+katG315+embB306+pncA47+gyrA94 | 1 |
| rpoB531+katG315+pncA59+pncA59+gyrA90 | 1 |
| rpoB531+katG315+embB88+rpsL88+pncA12+rrs | 1 |
| rpoB531+katG315+inhA+embB306+pncA171+rrs | 1 |
| rpoB406+katG315+embB531+embA+rpsL43+gyrA94 | 1 |
| rpoB531+katG315+inhA+embB306+rpsL43+pncA139+gyrA94 | 2 |
| rpoB531+katG315+rpsL43+embB406+gyrA94+pncA46+rrs | 1 |
Numbers after gene names indicate codon positions. The most common mutation sites were rpoB531, rpoB526, and katG315, consistent with known hot spots for rifampicin and isoniazid resistance.