Table 2.

Discontinuation reasons and definitions.

Class	Definition
Adverse reactions	Discontinuation due to adverse side effects, allergic reactions, or negative interactions with other medications
Treatment success	Discontinuation due to successful treatment completion or sufficient improvement in health
Treatment inefficacy	Perceived ineffectiveness of the treatment or loss of belief in its efficacy
Contraindication	Discontinuation due to the emergence or discovery of a medical condition or risk factor that makes the continued use of the treatment unsafe or inappropriate
Nonmedical reasons	Discontinuation due to factors unrelated to the patient’s health or the treatment’s medical effects, such as financial constraints, access issues, personal choice, cultural beliefs, or social circumstances
Other	Other medical reasons not explicitly covered by the other categories
Indeterminate	Unclear or unspecified reasons for discontinuation