Fig. 2.

Representative ALK break-apart FISH findings in canonical and noncanonical STRN::ALK-positive oncocytic thyroid tumors (a) Representative oncocytic thyroid carcinoma harboring a canonical in-frame STRN::ALK fusion demonstrating split ALK break-apart signals consistent with genomic rearrangement (b) Representative oncocytic thyroid tumor harboring a noncanonical out-of-frame STRN::ALK variant also demonstrating split ALK break-apart signals. White arrows indicate nuclei with rearranged ALK signals. Original magnification: ×1000