Table 2.

Molecular, Immunohistochemical, and Predicted Structural Features of Canonical and Noncanonical STRN::ALK-positive Oncocytic Thyroid Tumors

Case ID	Diagnosis	RT-PCR product size (bp)	Fusion type	ALK-rearranged nuclei (%)	ALK IHC	ALK kinase-domain features
4	OCA	50	Out-of-frame Type I	15	Negative	Disrupted
5	OCA	94	Canonical	58	Positive	Preserved
7	OCA	50	Out-of-frame Type II	13	Negative	Absent
9	OCA	50	Out-of-frame Type I	12	Negative	Disrupted
10	OCA	94	Canonical	23	Positive	Preserved
11	OCA	50	Out-of-frame Type I	15	Negative	Disrupted
12	OCA	50	Out-of-frame Type I	12	Negative	Disrupted
28	OA	50	Out-of-frame Type II	23	Negative	Absent
40	OA	50	Out-of-frame Type II	35	Negative	Absent

OCA Oncocytic Carcinoma of the Thyroid, OA Oncocytic Adenoma of the Thyroid