Table 3.
Structural modeling and physicochemical properties of predicted protein variants
| Parameter | Canonical | Type I | Type II |
|---|---|---|---|
| Length (aminoacids) | 700 | 685 | 145 |
| % residues > 90% confidence | 55% | 44% | 32% |
| Main template | Kinase (ALK-like) | Kinase-like (partial) | STRN (non-kinase) |
| Structural interpretation | Kinase domain preserved | Disruption of kinase domain | No kinase domain retained |
| Molecular weight | 77524.51 | 75651.35 | 15951.02 |
| Theoretical pI | 7.87 | 7.23 | 9.17 |
| Total number of negatively charged residues (Asp + Glu) | 78 | 77 | 17 |
| Total number of positively charged residues (Arg + Lys) | 80 | 77 | 21 |
| Formula | C3441H5396N962O1014S33 | C3357H5267N937O992S32 | C702H1103N213O206S4 |
| Total number of atoms | 10,846 | 10,585 | 2228 |
| The estimated half-life | 30 h | 30 h | 30 h |
| The instability index | 49.11 | 47.53 | 29.34 |
| Aliphatic index | 73.90 | 74.53 | 70.28 |
| Grand average of hydropathicity (GRAVY) | −0.488 | −0.469 | −0.610 |
| Cases presenting this protein conformation | 5 and 10 | 4, 9, 11, and 12 | 7, 28, and 40 |