Table 2. Reaction conditions and yields for “click” reaction (7 + 9b → 5).

Compound	Cu(i) source	Solvent	t, h	T, °C	Yield, %
5ab	Optimised conditionsa				82
5b	Optimised conditions				75
5c	Cu(PPh3)3Brc	MeCN : H2O = 1 : 1	24	r.t.	74
5db	Optimised conditions				57
5eb	Optimised conditions				59
5fb	Optimised conditions				57
5g	CuSO4·5H2O + sodium ascorbate	t-BuOH : H2O = 1 : 1	24	60	52
5h	Cu(PPh3)3Br	MeCN : H2O = 1 : 1	1.5	70	45
5i	Optimised conditions				29

^aCuSO₄·5H₂O, sodium ascorbate, Et₃N, AcOH, DMF : H₂O = 1 : 5, 40 °C, 24 h.

^bAzide 9b was not isolated (telescoped method).

^cAuramine was added.