eTable. Frequency of cardiac events between 2017–2021 in 5-year survivors of childhood cancer (diagnoses 1991–2011) and a matched*1 comparison group, stratified by sex and age.
| Frequency (N, %) | |||
|---|---|---|---|
| Survivors (N = 11 863) | Comparison group*1(N = 35 589) | Prevalence ratio 1 [95% CI] | |
| Cardiomyopathy*2 | |||
| Sex | |||
| Female | 98 (1.9%) | 14 (0.1%) | 21.0 [12.0; 36.8] |
| Male | 131 (2.0%) | 32 (0.2%) | 12.3 [8.4; 18.1] |
| Attained age at 1 January 2017 (years) | |||
| 5 to < 10 | 32 (4.0%) | 3 (0.1%) | 32.0 [9.8; 104.2] |
| 10 to < 20 | 113 (2.5%) | 9 (0.1%) | 38.1 [19.3; 75.1] |
| 20 to < 30 | 65 (1.3%) | 25 (0.2%) | 7.7 [4.9; 12.2] |
| ≥ 30 | 19 (1.3%) | 9 (0.2%) | 6.4 [2.9; 14.1] |
| Total | 229 (1.9%) | 46 (0.1%) | 14.9 [10.9; 20.5] |
| Valvular heart disease*3 | |||
| Sex | |||
| Female | 161 (3.1%) | 159 (1.0%) | 3.0 [2.5; 3.8] |
| Male | 162 (2.4%) | 139 (0.7%) | 3.5 [2.8; 4.4] |
| Attained age at 1 January 2017 (years) | |||
| 5 to < 10 | 18 (2.3%) | 11 (0.5%) | 4.9 [2.3; 10.4] |
| 10 to < 20 | 120 (2.7%) | 122 (0.9%) | 3.0 [2.3; 3.8] |
| 20 to < 30 | 132 (2.6%) | 118 (0.8%) | 3.3 [2.6; 4.2] |
| ≥ 30 | 53 (3.6%) | 47 (1.1%) | 3.4 [2.3; 5.0] |
| Total | 323 (2.7%) | 298 (0.8%) | 3.3 [2.8; 3.8] |
| Cardiac arrhythmia*4 | |||
| Sex | |||
| Female | 105 (2.0%) | 203 (1.3%) | 1.6 [1.2; 2.0] |
| Male | 75 (1.1%) | 205 (1.0%) | 1.1 [0.8; 1.4] |
| Attained age at 1 January 2017 (years) | |||
| 5 to < 10 | 8 (1.0%) | 11 (0.5%) | 2.2 [0.9; 5.4] |
| 10 to < 20 | 59 (1.3%) | 120 (0.9%) | 1.5 [1.1; 2.0] |
| 20 to < 30 | 86 (1.7%) | 186 (1.2%) | 1.4 [1.1; 1.8] |
| ≥ 30 | 27 (1.9%) | 91 (2.1%) | 0.9 [0.6; 1.4] |
| Total | 180 (1.5%) | 408 (1.2%) | 1.3 [1.1; 1.6] |
| Pericardial disease*5 | |||
| Sex | |||
| Female | 14 (0.3%) | 13 (0.1%) | 3.2 [1.5; 6.9] |
| Male | 14 (0.2%) | 17 (0.1%) | 2.5 [1.2; 5.0] |
| Attained age at 1 January 2017 (years) | |||
| 5 to < 10 | 0 (0.0%) | 0 (0.0%) | 0 |
| 10 to < 20 | 6 (0.1%) | 8 (0.1%) | 2.3 [0.8; 6.6] |
| 20 to < 30 | 14 (0.3%) | 17 (0.1%) | 2.4 [1.2; 5.0] |
| ≥ 30 | 8 (0.6%) | 5 (0.1%) | 4.8 [1.6; 14.8] |
| Total | 28 (0.2%) | 30 (0.1%) | 2.8 [1.7; 4.7] |
| Coronary heart disease*6 | |||
| Sex | |||
| Female | 20 (0.4%) | 23 (0.2%) | 2.6 [1.4; 4.8] |
| Male | 25 (0.4%) | 44 (0.2%) | 1.7 [1.0; 2.8] |
| Attained age at 1 January 2017 (years) | |||
| 5 to < 10 | 0 (0.0%) | 1 (0.0%) | 0 |
| 10 to < 20 | 6 (0.1%) | 6 (0.0%) | 3.0 [1.0; 9.4] |
| 20 to < 30 | 22 (0.4%) | 29 (0.2%) | 2.3 [1.3; 3.9] |
| ≥ 30 | 17 (1.2%) | 31 (0.7%) | 1.7 [0.9; 3.0] |
| Total | 45 (0.4%) | 67 (0.2%) | 2.0 [1.4; 2.9] |
| Cardiac insufficiency*7 | |||
| Sex | |||
| Female | 59 (1.1%) | 24 (0.2%) | 7.4 [4.6; 11.9] |
| Male | 58 (0.9%) | 41 (0.2%) | 4.2 [2.9; 6.3] |
| Attained age at 1 January 2017 (years) | |||
| 5 to < 10 | 5 (0.6%) | 1 (0.0%) | 15.0 [1.8; 128.2] |
| 10 to < 20 | 21 (0.5%) | 15 (0.1%) | 4.3 [2.2; 8.2] |
| 20 to < 30 | 62 (1.2%) | 32 (0.2%) | 5.7 [3.8; 8.8] |
| ≥ 30 | 29 (2.0%) | 17 (0.4%) | 5.2 [2.8; 9.4] |
| Total | 117 (1.0%) | 65 (0.2%) | 5.4 [4.0; 7.3] |
Matching criteria: age, sex, region of residence, duration of insurance
International Classification of Diseases (ICD-10): Heart failure/cardiomyopathy (I42); at least one recorded diagnosis in at least two different quarters during the SHI insurance period 2017–2021
International Classification of Diseases (ICD-10): Valvular heart disease (I34-I39); at least one recorded diagnosis in at least two different quarters during the SHI insurance period 2017–2021
International Classification of Diseases (ICD-10): Cardiac arrhythmia (I47-I49); at least one recorded diagnosis in at least two different quarters during the SHI insurance period 2017–2021
International Classification of Diseases (ICD-10): Pericardial disease (I31); at least one recorded diagnosis in at least two different quarters during the SHI insurance period 2017–2021
According to the International Classification of Diseases (ICD-10): coronary heart disease (I20-I25); at least one recorded diagnosis in at least two different quarters during the SHI insurance period 2017–2021
According to the International Classification of Diseases (ICD-10): cardiac insufficiency (I50); at least one recorded diagnosis in at least two different quarters during the SHI insurance period 2017–2021
CI, Confidence interval; SHI, statutory health insurance carrier; Survivors, 5-year survivors after childhood cancer