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. 2026 May 12;168(1):153. doi: 10.1007/s00701-026-06885-5

Table 1.

Study characteristics and patient demographics

Author (Year) Country Study design Sample size (n) Age (years) (mean ± SD or mean (range)) Sex (% male)
Total Pre Sim Post Pre Sim Post Pre Sim
Von der Brelie (2016) Germany RC 37 27 10 - 42.8 ± 17.9 - NR
Lin (2019) Taiwan RC 56 37 19 - 52.6 ± 15.6 57.5 ± 18.0 - 62.2 63.2
Heo (2014) Korea RC 51 19 32 - 55.3* 57.3* - 68.4 56.2
Rosinski (2020) USA RC 40 22 18 - 45.0 ± 10.6 54.7 ± 10.1 - 40.9 16.7
Ting (2020) Taiwan RC 49 32 17 - 51.2 ± 17.5 57.4 ± 13.7 - 65.6 70.6
Schuss (2015) Germany RC 41 21 17 3 53.0 ± 18.0 52.0 ± 13.0 53.0 ± 18.0 42.0 41.0
Urvas (2015) UK & Finland RC 68 43 3 22 39.7 ± 22.5 41.2 ± 18.2 43.8 ± 24.8 46.5 59.1
Gill (2021) Korea RC 81 37 18 26 62.5 ± 12.4 60.9 ± 15.3 62.5 ± 12.4 57.1 33.3
Zhang (2022) China RC 84 40 22 24 39.2 ± 11.6 50.0 (43.0–57.0) 47.7 (18.2) 90.0 81.8
Oh (2008) Korea RC 23 13 - 10 41.0 (25.0–65.0) - 41.0 (25.0–65.0) 60.0 -
Author (Year) Country Indication for DC (n) Bifrontal index (n) Degree of brain bulging (skin flap convexity) (n)
Post Pre Sim Post Pre Sim Post Pre Sim Post
Von der Brelie (2016) Germany -

TBI

Stroke*

- NR - NR -
Lin (2019) Taiwan -

TBI (24)

ICH (2)

SAH (4)

Infarct (6)

SDH (1)

TBI (15)

ICH (2)

Infarct (2)

- 0.39–0.46 (27) 0.36–0.43 (10) -

Flaccid concave (11)

Tense convex (26)

Flaccid concave (8)

Tense convex (11)

-
Heo (2014) Korea -

TBI (12)

SAH (12)

ICH (6)

Infarct (1)

IVH (1)

TBI (12)

SAH (12)

ICH (6)

Infarct (1)

IVH (1)

-

 ≥ 0.40 (6)

 < 0.40 (13)

 ≥ 0.40 (19)

 < 0.40 (13)

-

Flaccid concave (3)

Flaccid partial convex (4)

Tense convex (12)

Flaccid concave (0)

Flaccid partial convex (1)

Tense convex (31)

-
Rosinski (2020) USA -

Vascular (18)

Tumour/Infection (1)

Other (3)

Vascular (18) - NR - NR -
Ting (2020) Taiwan - NR -

 > 0.50 (10)

0.40–0.50 (7)

0.30–0.40 (1)

 > 0.50 (4)

0.40–0.50 (4)

0.30–0.40 (9)

-

Flaccid concave (1)

Flaccid partial convex (7)

Tense convex (24)

Flaccid concave (0)

Flaccid partial convex (9)

Tense convex (8)

-
Schuss (2015) Germany 42.0

TBI (10)

SAH (10)

ICH (2)

Infarct (2)

SAH (9)

TBI (5)

ICH (2)

Infarct (1)

TBI (10)

SAH (10)

ICH (2)

Infarct (2)

NR NR
Urvas (2015) UK & Finland 100.0

Hemorrhage (17)

TBI (12)

Infarct (4)

Other (10)

TBI (2)

Other (1)

TBI (10)

Hemorrhage (4)

Infarct (3)

Other (5)

NR NR
Gill (2021) Korea 57.1

TBI (16)

SAH (12)

ICH (5)

Infarct (2)

AVM (1)

SAH (10)

Infarct (3)

TBI (2)

ICH (2)

AVM (1)

TBI (11)

SAH (9)

ICH (4)

Infarct (2)

AVM (1)

0.34 ± 0.03 (37) 0.37 ± 0.08 (18) 0.34 ± 0.03 (26)

Flaccid concave (5)

Tense convex (32)

Flaccid concave (0)

Tense convex (18)

Flaccid concave (3)

Tense convex (23)

Zhang (2022) China 70.8

TBI (20)

ICH (14)

SAH (6)

TBI (13)

ICH (6)

SAH (3)

TBI (17)

ICH (5)

SAH (2)

NR

Flaccid concave (1)

Tense convex (39)

Flaccid concave (3)

Tense convex (19)

Flaccid concave (9)

Tense convex (15)

Oh (2008) Korea 61.5

TBI (9)

Infarct (2)

SAH (2)

-

TBI (7)

Infarct (2)

SAH (1)

 > 0.40 (13) -  > 0.40 (10) NR

Baseline characteristics of included studies comparing pre-cranioplasty (CP) ventriculoperitoneal shunting (VPS), simultaneous CP-VPS, and post-CP VPS. Reported variables include study design, sample size, age, sex distribution, follow-up duration, indication for DC, radiographic indices used to define hydrocephalus (where available), and qualitative assessment of brain contour or bulging at the time of intervention. Data is reported at the study arm level where available. Not all variables were available for all timing strategies

Abbreviations & Symbols: CP Cranioplasty, DC Decompressive Craniectomy, VPS Ventriculoperitoneal Shunting, Pre VPS prior to CP, Sim VPS at the time of CP (i.e. simultaneous), Post VPS after CP, RC Retrospective Cohort, DC Decompressive Craniectomy, TBI Traumatic Brain Injury, ICH Intracerebral Hemorrhage, IVH Intraventricular Hemorrhage, SAH Subarachnoid Hemorrhage, SDH Subdural Hemorrhage, AVM Arteriovenous Malformation, NR Not Reported; *Cell where mean and/or standard deviation and/or range and/or n-number not reported