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. Author manuscript; available in PMC: 2026 Jul 8.
Published in final edited form as: Lancet Neurol. 2026 Jun;25(6):581–590. doi: 10.1016/S1474-4422(26)00123-7

Table 2:

Genome-wide significant loci

rsID SNV p OR (95% CI) MAF cases/controls MAF NFE
CNIH4 rs74546314 1:224365900:G:A 1·05 × 10−9 11·99 (5·39–26·64) 0.044/0·004 0·003
ALK rs78120946 2:29324788:T:A 3·78 × 10−8 7·21 (3·56–14·57) 0.054/0·008 0·011
CCNG1 rs537168961 5:162973378:C:T 3·05 × 10−8 9·56 (4·29–21·24) 0.045/0·005 0·008
RHOJ rs141931440 14:63196126:C:T 2·77 × 10−10 5·96 (3·42–10·36) 0.089/0·021 0·018

Genome-wide significant loci (p<5·0 × 10−8) identified in case–control genome-wide association study analysis. rsID=Single Nucleotide Polymorphism Database reported variant identification number. SNV=single nucleotide variant (chromosome [GRCh38], base-pair position, reference allele, alternative allele). OR=odds ratio. MAF=minor allele frequency. NFE=Genome Aggregation Database (gnomAD) non-Finnish European.