TABLE 1.
Donor characteristics and graft baseline parameters
| Group A (N = 8) |
Group B (N = 7) |
Group C (N = 5) |
P | |
|---|---|---|---|---|
| Donor’s characteristics | ||||
| Donor age, y, median (IQR) | 55.0 (40.0–79.0) | 76.0 (55.0–88.0) | 69.0 (44.5–74.0) | 0.7 |
| Donor male, n (%) | 6 (75.0%) | 5 (71.4%) | 3 (60.0%) | 0.8 |
| Donor type, n (%) | ||||
| uDCD | 4 (50.0%) | 1 (14.3%) | 4 (80.0%) | 0.2 |
| cDCD | 3 (37.5%) | 4 (57.1%) | 1 (20.0%) | |
| DBD | 1 (12.5%) | 2 (28.6%) | 0 (0%) | |
| Cause of death, n (%) | ||||
| CVA | 4 (50.0%) | 2 (28.6%) | 4 (80.0%) | 0.2 |
| Stroke | 4 (50.0%) | 5 (71.4%) | 1 (20.0%) | |
| Previous medical history, n (%) | ||||
| High blood pressure | 6 (75.0%) | 5 (71.4%) | 3 (60.0%) | 0.8 |
| DM | 2 (25.0%) | 2 (28.6%) | 4 (80.0%) | 0.1 |
| Cardiovascular disease | 2 (25.0%) | 4 (57.1%) | 2 (40.0%) | 0.4 |
| Serum creatinine, mg/dL, median (IQR) | 1.0 (0.9–1.3) | 1.0 (0.9–1.1) | 1.0 (0.9–1.2) | 0.9 |
| Graft baseline parameters | ||||
| Cold ischemia time, h, median (IQR) | 12.5 (9.8–17.8) | 14.0 (11.5–15.1) | 17.0 (12.0–25.0) | 0.5 |
| Right-sided graft, n (%) | 5 (62.5%) | 4 (57.1%) | 3 (60.0%) | 0.9 |
| Organ preservation solution, n (%) | ||||
| IGL-1 | 4 (50.0%) | 3 (42.9%) | 2 (40.0%) | 0.4 |
| Celsior | 2 (25.0%) | 3 (42.9%) | 0 (0%) | |
| HTK-Custodiol | 2 (25.0%) | 1 (14.3%) | 3 (60.0%) | |
| Reason for discard, n (%) | ||||
| Inadequate in situ perfusion | 5 (62.5%) | 2 (28.6%) | 4 (80.0%) | 0.3 |
| Donor previous medical history of metastatic prostate cancer | 0 (0%) | 2 (28.6%) | 0 (0%) | |
| Poor organ qualitya | 2 (25.0%) | 3 (42.9%) | 1 (20.0%) | |
| Kidney tumor on contralateral kidney | 1 (12.5%) | 0 (0%) | 0 (0%) | |
| No. of arteries, n (%) | ||||
| 1 | 6 (75.0%) | 6 (85.7%) | 4 (80.0%) | 0.5 |
| 2 | 1 (12.5%) | 1 (14.3%) | 0 (0%) | |
| 3 | 1 (12.5%) | 0 (0%) | 0 (0%) | |
| 4 | 0 (0%) | 0 (0%) | 1 (20.0%) | |
| No. of veins, n (%) | ||||
| 1 | 8 (100%) | 7 (100%) | 5 (100%) | 0.9 |
aRemuzzi Score: 4 or 5.
cDCD, controlled donation after circulatory death; CVA, cardiovascular arrest; DBD, donation after brain death; DM, diabetes mellitus; HTK, histidine-tryptophan-ketoglutarate; IGL-1, Institut Georges Lopez-1; IQR, interquartile range; uDCD, uncontrolled DCD.