Table 1.
Expression differences between BSA and saline treatment
| Gene name/Function | ID | Expression ratios | p values | ||||
| T1/C1 | T2/C2 | T3/C3 | T1/C1 | T2/C2 | T3/C3 | ||
| Kidney function | |||||||
| Ornithine transcarbamylase (OTC) | [Genbank:X07094] | 1 | 1.7 | 1 | NS | 2.66E-05 | NS |
| Folate receptor 1 (Folr1) | [Genbank:XM_133582] | 1 | 1.8 | 1 | NS | 4.12E-04 | NS |
| Lipid Metabolism | |||||||
| Insulin induced gene 1 (Insig1) | [Genbank:NM_153526] | 1 | 1.8 | 1 | NS | 8.05E-04 | NS |
| VAMP associated protein A (VAPA) | [Genbank:BC003866] | 0.7 | 1 | 1 | 2.47E-03 | NS | NS |
| Acetyl-CoA transporter (AcylCoAtrsp) | [Genbank:BC005616] | 0.7 | 1 | 1 | 3.13E-02 | NS | NS |
| Immune | |||||||
| Calmodulin-dependent protein kinase beta (CaMKII) | [Genbank:XM_132366] | 1.4 | 1.9 | 1.6 | 3.63E-02 | 4.86E-03 | 3.23E-04 |
| Homolog human calcineurin B, type I (Calcineurin BI) | [Genbank:BC027913] | 1 | 1.8 | 1.4 | NS | 9.99E-04 | 1.45E-02 |
| Platelet Endothelial Cell Adhesion Molecule 1 (PECAM1) | [Genbank:BC008519] | 1 | 2.1 | 1 | NS | 1.98E-04 | NS |
| SPRY domain-containing SOCS box 4 (SSB-4) | [Genbank:NM_145134] | 1 | 1.8 | 1 | NS | 4.54E-04 | NS |
| Signal Transduction | |||||||
| Homolog diacylglycerol kinase, theta (HmlgDAGKθ) | [Genbank:NM_199011] | 1.3 | 1.9 | 1.6 | 1.93E-02 | 4.54E-03 | 3.08E-04 |
| Glucocorticoid receptor | |||||||
| Immunophilin FKBP-52 (FKBP52) | [Genbank:X17069] | 1 | 0.8 | 0.8 | NS | 6.81E-03 | 3.27E-03 |
| Apoptosis | |||||||
| Insulin-like Growth factor2 binding protein1 (IGF2bp1) | [Genbank:XM_109627] | 1 | 2 | 1.5 | NS | 9.40E-04 | 7.71E-04 |
| Homolog apoptosis-related PNAS2 (Hmlg.apopts) | [Genbank:AK008911] | 0.9 | 1 | 1 | 4.88E-02 | NS | NS |
| Histone Acetylase subunit MRG15-1 (HistAcetyl) | [Genbank:AF319620] | 0.7 | 1 | 0.7 | 4.36E-02 | NS | 2.07E-02 |
| DEAD/H box polypeptide 3 (DEAD3) | [Genbank:NM_010028] | 1 | 1.6 | 1.4 | NS | 8.25E-04 | 6.26E-03 |
| Ribosomal protein S23 (rib. prot. S23) | [Genbank:AK012574] | 1.3 | 1 | 1 | 4.06E-02 | NS | NS |
| Ribosomal protein L21 (RpL21) | [Genbank:U93863] | 0.8 | 1 | 1 | 3.72E-02 | NS | NS |
| t-complex polypeptide 1 (tcp-1) | [Genbank:D10606] | 1 | 1.9 | 1 | NS | 5.27E-04 | NS |
| Mannosidase 2, alpha 1 (Man2a1) | [Genbank:XM_123163] | 1 | 1.4 | 1.5 | NS | 2.43E-04 | 5.85E-03 |
| Mitochondrial | |||||||
| Type 6 control region flanking tRNA (mtDNACtrlRNA) | [Genbank:U47435] | 0.6 | 1 | 1 | 1.70E-02 | NS | NS |
| tRNA-Thr gene (tRNA-Thr) | [Genbank:AJ313380] | 0.6 | 1.7 | 1 | 3.59E-02 | 2.72E-04 | NS |
| 16S ribosomal RNA gene (t16srRNA) | [Genbank:AY011146] | 1 | 0.7 | 0.8 | NS | 7.65E-04 | 2.88E-02 |
| Mouse mitochondrion, complete genome (Mitochond.) | [Genbank:J01420] | 1 | 1.3 | 1.1 | NS | 1.42E-03 | 3.22E-02 |
| Solute carrier family 25 member 3 (Slc25a3) | [Genbank:BC018161] | 0.7 | 1 | 1 | 2.38E-02 | NS | NS |
| Cytochrome c oxidase subunit VIIb (Cox7b) | [Genbank:NM_025379] | 0.8 | 1 | 1 | 1.60E-02 | NS | NS |
| Protection against radicals | |||||||
| Ferritin heavy chain 1 (Fth1) | [Genbank:NM_010239] | 1 | 1.5 | 1.3 | NS | 1.66E-05 | 4.17E-02 |
| Organelle transport | |||||||
| Homolog rat dynein LIC-2 53/55 (HmlgratDncli2) | [Genbank:NM_031026] | 1 | 1.4 | 1 | NS | 9.46E-05 | NS |
| Reduction of aromatic aldehydes | |||||||
| Aldehyde dehydrogenase 3B1 (ALDH3B1) | [Genbank:XM_129078] | 1 | 1.7 | 1.4 | NS | 4.17E-04 | 3.71E-02 |
| Unknown | |||||||
| Clone RP23-465D7 on chromosome 11 (RP23-465D7) | [Genbank:AL591486] | 0.6 | 1 | 0.7 | 3.11E-02 | NS | 1.93E-02 |
| Hypothetical-Binding-protein-dependent transport (Hp) | [Genbank:AK010392] | 1.5 | 1.5 | 1.5 | 1.53E-02 | 3.29E-02 | 5.59E-03 |
| Clone ct7-25g12 (ct7-25g12) | [Genbank:AC093447] | 0.7 | 1 | 1 | 8.92E-04 | NS | NS |
T1: NOD.B10 treated with BSA, C1: NOD.B10 saline controls, T2: NON treated with BSA, C2: NON saline controls, T3: combined analysis of NOD.B10 and NON treated with BSA, C3: combined analysis of NOD.B10 and NON saline control. NS: Non Significant. Genes found to discriminate between any two of the groups of mice are represented. For each gene, the mean expression value ratio between treated and control animals are represented. Student test p values obtained for significant comparison are also shown.